In the modern conditions of conducting various branches of animal husbandry, scientific achievements and practical experience in matters of hygienic research are summarized, as well as the main priorities of scientific research in hygiene, ethology, welfare, care, exploitation and disease prevention of agricultural animals under conditions of sustainable production of various types of animal husbandry products and raw materials are determined for food and processing industries. The importance of veterinary sanitation in the prevention of animal diseases, increasing their productivity and reproductive capacity during the transfer of genetic potential is scientifically substantiated. The analysis of the influence of external factors (air, water, feed, technological methods, zoohygiene regimes and standards) on the formation of the natural resistance of the organism, increasing productivity, preservation and impact on the quality of the obtained products is presented. On the basis of the above, it can be concluded that only on the basis of the existing scientific work created in the scientific schools of institutions and educational institutions, the acquired global practical experience and the implementation of new theoretical approaches and practical techniques in the hygiene of agricultural animals into the practice of animal husbandry, it is possible to ensure comfortable conditions of keeping, care and exploitation of animals, prevent stress, preserve the health of animals, and make the production of products environmentally friendly and more efficient. The areas of further research in the prevention of animal diseases and the training of students of agricultural universities in the specialty" Veterinary hygiene, sanitation and expertise" are highlighted.