The high lability of the composition of the skin, its content of sulfur and nitrogen, the dependence of the composition of the skin on the nature of the diet, allows us to talk about its significant depositing role. Deposition of sulfur- containing compounds in the skin was also shown using autoradiographic examination of tissues of animals treated with S35. Sulfur-containing compounds enter the skin immediately after their introduction to the animal in its native form or after recovery and peresulfonation. They are deposited in large quantities in the subcutaneous tissue, in hair follicles. In rodents, the largest primary deposition is observed in the neck of the follicle, surrounded by a dense network of capillaries, blood sinuses, and in adult sheep, lambs, saigas - mainly in the bulbs. Active processes of sulfur exchange take place in the skin, its oxidized compounds are reduced to sulfides, then passes their inclusion in the composition of organic molecules. The reduction of sulfur sulfate and its incorporation into amino acids is rapid. In lambs that received per os radioactive methionine or sodium sulfate S35, the composition of methionine and cystine was detected in the skin already 5-10 minutes after administration.