Based on the analysis of literary sources, a generalized classification of antimicrobial substances, which should be included in biodegradable packaging, is proposed. It was established that the introduction of antimicrobial biodegradable packaging TiO2 in the amount of 1% into the composition of the molding solution allows to give the developed material antibacterial properties, since the vital activity of some microorganisms is suppressed. Research results show that TiO2 as part of the packaging really inhibits the development of bacteria Escherichia coli IEM-1, Bacillus subtilis BT-2, as there is a delay in the growth of their colonies. Therefore, the results of the study make it possible to recommend TiO2 as an effective tool to combat potato disease.