SYNTHESIS AND BIOLOGICAL PROPERTIES OF IMINES OF METHYL ESTER OF p-AMINOBENZOIC ACID

Authors

DOI:

https://doi.org/10.30890/2567-5273.2025-41-02-044

Keywords:

methyl ester of p-aminobenzoic acid, imines, in silico prediction, DPPH.

Abstract

The synthesis of imines was carried out by the interaction of methyl ester of p-aminobenzoic acid and aromatic aldehydes. The drug-likeness parameters were determined and the probable acute toxicity of the obtained imines was predicted using the followin

References

W. Al Zoubi and Y. G. Ko. Schiff base complexes and their versatile applications as catalysts in oxidation of organic compounds: part I. Appl. Organomet. Chem. 2017. Vol. 31, № 3. Р. 1-12. DOI: 10.1002/aoc.3574

E. Raczuk, B. Dmochowska, J. Samaszko-Fiertek, and J. Madaj. Different Schiff Bases – Structure, Importance and Classification. Molecules. 2022. Vol. 27, №3. Р. 1-24. doi.org/10.3390/molecules27030787

Kobzar, O. L.; Tatarchuk, A. V.; Kachaeva, M. V.; Pilyo, S. G.; Sukhoveev, O. V.; Sukhoveev, V. V.; Brovarets, V. S.; Vovk, A. I. Azomethine derivatives of p-aminobenzoic acid as antioxidants and inhibitors of xanthine oxidase Supplement. National Acad. of Sciences Ukr. 2020. № 6. С. 74-82. DOI: 10.15407/доповіді2020.06.074

V. Kuchtanin, L. Klešcíková, M. Šoral, R. Fischer, Z. Ruzicková, E. Rakovsky, J. Moncola and P. Segla. Nickel(II) Schiff base complexes: Synthesis, characterization and catalytic activity in Kumada-Corriu cross-coupling reactions. Polyhedron. 2016. Vol. 117. P. 90-96. DOI: 10.1016/j.poly.2016.05.037

Dobbs A.P., Rossiter S. Imines and their N-substituted derivatives: NH, NR, and N-Haloimines. Comprehensive Organic Functional Group Transformations II. 2005. Vol. 3. P. 419-450. doi.org/10.1016/B0-08-044655-8/00055-6

Varma R.S., Dahiya R., Kumar S. Clay catalyzed synthesis of imines and enamines undersolvent-free conditions using microwave irradiation. Tetrahedron Lett. 1997. Vol. 38, № 12. P. 2039-2042. https://doi.org/10.1016/S0040-4039(97)00261-X

http://www.swissadme.ch/.

https://tox.charite.de/protox3/.

Foti M.C. Use and Abuse of the DPPH• Radical. J. Agric. Food Chem. 2015. Vol. 63, № 40. Р. 8765-8776. DOI: 10.1021/acs.jafc.5b03839

Boulebd H. Comparative study of the radical scavenging behavior of ascorbic acid, BHT, BHA and Trolox: Experimental and theoretical study. J. Mol. Struct. 2020. Vol. 1201. P. 127210. https://doi.org/10.1016/j.molstruc.2019.127210

Published

2025-10-30

How to Cite

Барус, М., Скрипська, О., & Бінкова, В. (2025). SYNTHESIS AND BIOLOGICAL PROPERTIES OF IMINES OF METHYL ESTER OF p-AMINOBENZOIC ACID. Modern Engineering and Innovative Technologies, 2(41-02), 195–205. https://doi.org/10.30890/2567-5273.2025-41-02-044

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Articles