СИНТЕЗ ТА ХІМІЧНИЙ ПОТЕНЦІАЛ ГІБРИДНИХ СТРУКТУР З ОКСАДІАЗОЛЬНИМИ ЯДРАМИ ПІРАЗОЛУ ТА ТІОФЕНУ

Наталія Панасенко; Надія Панасенко

doi:10.30890/2567-5273.2022-21-01-071

Автор(и)

Наталія Панасенко Буковинський державний медичний університет
Надія Панасенко Буковинський державний медичний університет

DOI:

https://doi.org/10.30890/2567-5273.2022-21-01-071

Ключові слова:

hybrid structures, 3-(4-pyrazolyl)-5-(1, 2, 4)-oxadiazolyl acetonitriles, 4-pyrazolyl-5-(1, 4)-oxadiazolyl-3-thienylamines, cyclocondensation

Анотація

By cyclocondensation of 4-pyrazolylamidooximes with N-cyanoacetyl-3,5-dimethylpyrazole 3-(4-pyrazolyl)-5-(1,2,4-oxadiazolyl)acetonitriles were synthesized. By interaction of these compounds with sulfur and cycloalkanones in the conditions of Gewald reacti

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Посилання

Mehta G., Singh V. Hybrid systems through natural product leads: an approach towards new molecular entities // Chem. Soc Rev. – 2002. - vol. 31. – P. 324-334.

Meunier B. Hybrid molecules with a dual mode of action: dream or reality // Acc. Chem. Res. – 2008. – vol. 41. – P. 69-77.

Kumar H., Saini D., Jain S., Jain N., Pyrazole scaffold: a remarkable tool in the development of anticancer agents // Eur. J. Med. Chem. – 2013. – Vol. 70. – P. 248-258.

Perez-Fernandez R., Goya P., Elguero J. A review of recent progress (2002-2012) on the biological activities of pyrazoles // Arkivoc. – 2014. – Vol. ІІ. – P. 233-293.

Datar P. A., Jadhav S. R. Development of pyrazole compounds as antidiabetic agent: a review // Lett. Drug Design Discovery. – 2014. – Vol. 11. – P. 686-703.

Bora R. O., Dar B, Prodhan V. et al. [1,2,4]-Oxadiazoles: synthesis and biological applications // Mini Rev. Med. Chem. – 2014. – Vol. 14. – P. 355-369.

Zhu J, Ye Y, Ning et al. Design, synthesis, and structure-activity relationships of 3,4,5-trisubstituted 4,5-dihydro-1,2,4-oxadiazoles as TGR5 agonists // Chem. Med. Chem. – 2013. – Vol. 8. – P. 1210-1223.

Behbehani H, Ibrahim H. M, Makhseed S et al. 2-Aminothiophenes as building blocks in heterocyclic synthesis: synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives // Eur. J. Chem. Med. Chem. – 2012. – Vol. 52. – P. 51-65.

Fogue P. S, Lunga P. K., Fondjo E. S. et al. Substituted 2-aminothiophenes: antifungal activities and effect on Microsporum gypseum protein profile // Mycoses. – 2012. – Vol. 55, № 4. –P. 310-307.

Aurelio L., Christopoulos A., Flynn B.L. et al. The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor // Bioorg. Chem. Lett. – 2011. – Vol. 21. – P. 3704-3707.

Aurelio L., Figler H., Flynn B. L. et al. 5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers // Bioorg. Med. Chem. – 2008. – Vol. 16. – P. 1319-1327.

Bratenko M. K., Panasenko N. V., Vovk M. V. Synthesis novykh pokhidnykh 3-(pirazol-4-il)-1,2,4-oksadiazolu // Nauk. Visn. Chernivetskoho. Univer. – 2012. – Vyp. 606. – S. 19-23.

Young J. R., Devita R. J. Novel Synthesis of oxadiazoles via palladium catalysis // Tetrahedron lett. – 1998. – Vol. 39. – P. 3931-3934.

Messer W. S., Abuh Y. F., Liu Y. et al. Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists // J. Med. Chem. – 1997.– Vol. 40. – P. 1230-1246.

Orlek B. S., Blaney F. E., Brown F. et al. Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor // J. Med. Chem. – 1991. – Vol. 34. – P. 2726-2735

Watjen F., Baker R., Engelstoff M. et al. Novel benzodiazepine receptor partial agonists: oxadiazolylimidazobenzodiazepines // J. Med. Chem. – 1989. – Vol. 32. – P. 2282-2291

Clitherow J. W., Beswick P., Irving W. J. at al. Novel 1, 2, 4-oxadiazoles as potent and selective histamine H3 receptor antagonists // Bioorg. Med. Chem. Lett. – 1996. – Vol. 6. – P. 833-838.

Pat. WO 2014040938 (A1) Non-annulated thiophenylamides as inhibitors of fatty acid binding proteini(fabp) 4 and /or 5 / Buettelmann B., Ceccarelli S., Kuehne H., Kuhn B., Neidhart W., Obst S. U., Richter H. Publ. 20.03.2014. // http // espacenet.com

Pat. US 2015183778 (A1) New non-annulated thiophenylamides / Buettelmann B., Ceccarelli S., Kuehne H., Kuhn B., Neidhart W., Obst S. U., Richter H. Publ. 02.07.2015. // http // espacenet.com

Pat. WO 2013189841 (A1) New bicyclic thiophenylamide compounds / Buettelmann B., Ceccarelli S., Kuehne H., Kuhn B., Neidhart W., Obst S. U., Richter H. Publ. 27.12.2013 // http // espacenet.com